Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | GALR2 | O43603 | 1/20 | 0.42 |
| ▸ | GALR1 | P47211 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24847590 | 1.00 | BACE1 (0.45) | BACE1TLR9ALKMAPTLMNA | |
| SCHEMBL26071980 | 0.87 | LMNA (0.46) | BACE1MAPTLMNAALDH1A1HPGD | |
| SCHEMBL30180025 | 0.86 | LMNA (0.49) | BACE1TLR9ALKMAPTLMNA | |
| SCHEMBL24847131 | 0.86 | LMNA (0.49) | BACE1TLR9ALKMAPTLMNA | |
| SCHEMBL30965619 | 0.85 | SMARCA2 (0.47) | BACE1TLR9ALKMAPTLMNA | |
| SCHEMBL21833197 | 0.85 | LMNA (0.46) | BACE1MAPTLMNAALDH1A1HPGD | |
| SCHEMBL14852278 | 0.82 | BACE1 (0.55) | BACE1TLR9MAPTLMNAALDH1A1 | |
| SCHEMBL31487397 | 0.81 | MAPT (0.52) | MAPTLMNAALDH1A1SMN1; SMN2KCNH2 | |
| SCHEMBL30965662 | 0.81 | MAPT (0.52) | MAPTLMNAALDH1A1SMN1; SMN2KCNH2 | |
| SCHEMBL24187350 | 0.81 | GPR119 (0.43) | BACE1MAPTLMNAALDH1A1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278759-A1 | MK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |