Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDAH1 | O94760 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28095616 | 0.78 | RAB9A (0.62) | RAB9ANPC1SMN1; SMN2MEN1MAPT | |
| SCHEMBL8031188 | 0.77 | RAB9A (0.65) | RAB9ANPC1SMN1; SMN2MEN1MAPT | |
| Ammonia Solution, Strong SCHEMBL10619768 | 0.75 | RAB9A (0.63) | RAB9ANPC1SMN1; SMN2MEN1MAPT | |
| SCHEMBL17153866 | 0.75 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2MEN1MAPT | |
| Ammonia Solution, Strong SCHEMBL10619764 | 0.75 | RAB9A (0.63) | RAB9ANPC1SMN1; SMN2MEN1MAPT | |
| SCHEMBL6319718 | 0.74 | ALDH1A1 (0.66) | RAB9ANPC1SMN1; SMN2MEN1MAPT | |
| Zinc Ion SCHEMBL11742498 | 0.74 | RAB9A (0.57) | RAB9ANPC1SMN1; SMN2MEN1MAPT | |
| SCHEMBL2170056 | 0.73 | ALDH1A1 (0.64) | RAB9ANPC1SMN1; SMN2MEN1MAPT | |
| SCHEMBL28727291 | 0.73 | SMN1; SMN2 (0.65) | RAB9ANPC1SMN1; SMN2MEN1MAPT | |
| SCHEMBL836745 | 0.73 | SMN1; SMN2 (0.65) | RAB9ANPC1SMN1; SMN2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2522394-B1 | Substituted phosphonates and their use decreasing amyloid aggregates | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2016-12-28 | — | — | EP | disclosed |
| US-8513219-B2 | Substituted phosphonates and their use in decreasing amyloid aggregates | QUEEN MARY & WESTFIELD COLLEGE, UNIVERSITY OF LONDON (GB) | 2013-08-20 | — | — | US | disclosed |
| EP-2522394-A2 | Substituted phosphonates and their use decreasing amyloid aggregates | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2012-11-14 | — | — | EP | disclosed |
| US-20100204183-A1 | Substituted Phosphonates and Their Use In Decreasing Amyloid Aggregates | QUEEN MARY & WESTFIELD COLLEGE (GB) | 2010-08-12 | — | — | US | disclosed |
| EP-2152368-A1 | SUBSTITUTED PHOSPHONATES AND THEIR USE IN DECREASING AMYLOID AGGREGATES | Queen Mary and Westfield College (GB) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008135743-A1 | SUBSTITUTED PHOSPHONATES AND THEIR USE IN DECREASING AMYLOID AGGREGATES | QUEEN MARY AND WESTFIELD COLLEGE (GB) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204183-A1 | Substituted Phosphonates and Their Use In Decreasing Amyloid Aggregates | PSEN2, PSEN1, APP | DDAH1 715/4885RAB9A 3436/4885NPC1 652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.