Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 10/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 2/20 | 0.32 |
| ▸ | IGF1R | P08069 | 2/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | KIF5B | P33176 | 1/20 | 0.31 |
| ▸ | ESRRB | O95718 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESRRA | P11474 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29172306 | 1.00 | KDM4E (0.37) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL18812797 | 0.81 | PIN1 (0.44) | ALDH1A1PIN1INSRIGF1RALK | |
| SCHEMBL30875696 | 0.81 | PIN1 (0.44) | ALDH1A1PIN1INSRIGF1RALK | |
| SCHEMBL25947639 | 0.80 | ALDH1A1 (0.38) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL29172293 | 0.79 | PIN1 (0.43) | MEN1KMT2AALDH1A1PIN1SMN1; SMN2 | |
| SCHEMBL30875700 | 0.79 | PIN1 (0.43) | MEN1KMT2AALDH1A1PIN1SMN1; SMN2 | |
| Phosphine SCHEMBL25950919 | 0.75 | KDM4E (0.35) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL23933001 | 0.73 | INSR (0.47) | INSRIGF1RALKEGFR | |
| SCHEMBL30776709 | 0.67 | MEN1 (0.41) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL19103241 | 0.67 | ALDH1A1 (0.39) | KDM4EALDH1A1GAAPIN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4367123-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | Glenmark Specialty S.A. (CH) | 2024-05-15 | — | — | EP | disclosed |
| CN-117730083-A | Pyrimidine compounds as MAP4K1 inhibitors | 格兰马克专业公司 | 2024-03-19 | — | — | CN | disclosed |
| WO-2023281417-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | GLENMARK SPECIALTY S.A. (CH) | 2023-01-12 | — | — | WO | disclosed |