Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | PIK3C3 | Q8NEB9 | 7/20 | 0.50 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16923772 | 1.00 | JAK2 (0.51) | JAK2JAK1TYK2PIK3C3RIOK2 | |
| SCHEMBL29393227 | 0.84 | ATR (0.46) | RIOK2NTRK1SORT1RAB9ASMN1; SMN2 | |
| SCHEMBL1133582 | 0.84 | ATR (0.46) | RIOK2NTRK1SORT1RAB9ASMN1; SMN2 | |
| SCHEMBL28698577 | 0.84 | PIK3C3 (0.48) | PIK3C3RIOK2NTRK1SORT1RAB9A | |
| SCHEMBL29899021 | 0.82 | L3MBTL1 (0.55) | JAK2JAK1TYK2PIK3C3RIOK2 | |
| SCHEMBL355579 | 0.82 | L3MBTL1 (0.55) | JAK2JAK1TYK2PIK3C3RIOK2 | |
| SCHEMBL1555088 | 0.81 | HPGD (0.54) | RIOK2NTRK1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL25600283 | 0.81 | JAK2 (0.52) | JAK2JAK1TYK2PIK3C3RAB9A | |
| Ammonia Solution, Strong SCHEMBL28494689 | 0.81 | L3MBTL1 (0.53) | JAK2JAK1TYK2PIK3C3RIOK2 | |
| SCHEMBL10276435 | 0.81 | TP53 (0.60) | JAK2JAK1TYK2SORT1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343720-A1 | AAK1 INHIBITOR AND USE THEREOF | XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2024-10-17 | — | — | US | disclosed |
| EP-4371980-A1 | AAK1 INHIBITOR AND USE THEREOF | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2024-05-22 | — | — | EP | disclosed |
| WO-2023284838-A1 | AAK1 INHIBITOR AND USE THEREOF | 四川海思科制药有限公司 | 2023-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343720-A1 | AAK1 INHIBITOR AND USE THEREOF | AAK1, ADCK1, ADCK5 | JAK2 805/4885JAK1 720/4885TYK2 162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.