Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18356528 | 0.82 | ALDH1A1 (0.64) | SMN1; SMN2KDM4EALDH1A1NOTUMRAB9A | |
| SCHEMBL29626186 | 0.77 | POLB (0.44) | HPGDTSHRSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL30672148 | 0.77 | MERTK (0.42) | HPGDSMN1; SMN2KDM4EALDH1A1NPSR1 | |
| SCHEMBL13369853 | 0.75 | KLKB1 (0.63) | — | |
| SCHEMBL30672466 | 0.75 | ALDH1A1 (0.43) | HPGDSMN1; SMN2KDM4EALDH1A1RAB9A | |
| SCHEMBL30672493 | 0.74 | ALDH1A1 (0.43) | HPGDTSHRSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL30672459 | 0.74 | SMN1; SMN2 (0.38) | HPGDTSHRSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20033206 | 0.73 | SMN1; SMN2 (0.51) | HPGDSMN1; SMN2KDM4EALDH1A1RAB9A | |
| SCHEMBL28802530 | 0.73 | ALDH1A1 (0.68) | HPGDSMN1; SMN2KDM4EALDH1A1RAB9A | |
| SCHEMBL22631221 | 0.72 | KMT2A (0.67) | TSHRSMN1; SMN2ALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115536648-A | Polycyclic compound for inhibiting RNA helicase DHX33 and application thereof | 深圳开悦生命科技有限公司 | 2022-12-30 | — | — | CN | disclosed |