Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM1 | P23921 | 2/20 | 0.50 |
| ▸ | RRM2B | Q7LG56 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.41 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | KDM4B | O94953 | 2/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.41 |
| ▸ | MRE11 | P49959 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21484881 | 0.76 | EGFR (0.53) | KDM4EMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL30186382 | 0.72 | RRM1 (0.53) | RRM1RRM2BKDM4EMAPTMEN1 | |
| SCHEMBL30186374 | 0.71 | RRM1 (0.49) | RRM1RRM2BKDM4EMAPTMEN1 | |
| SCHEMBL28510115 | 0.70 | MAPT (0.57) | RRM1RRM2BMAPTMEN1ALDH1A1 | |
| SCHEMBL21484761 | 0.68 | ABL1 (0.57) | ADORA3KDM4AKDM4BKDM5BKDM4E | |
| SCHEMBL10036571 | 0.67 | RRM1 (1.00) | RRM1RRM2BKDM4EMAPTMEN1 | |
| SCHEMBL11137540 | 0.66 | RRM1 (0.70) | RRM1RRM2BMRE11KDM4EMAPT | |
| SCHEMBL21505929 | 0.65 | RRM1 (0.57) | RRM1RRM2BADORA3MRE11MAPT | |
| SCHEMBL21505930 | 0.65 | RRM1 (0.57) | RRM1RRM2BADORA3MRE11MAPT | |
| SCHEMBL30186439 | 0.65 | RRM1 (0.57) | RRM1RRM2BADORA3MRE11MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584742-B2 | Substituted aminothiazoles as inhibitors of nucleases | MASARYKOVA UNIVERZITA (CZ) | 2023-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584742-B2 | Substituted aminothiazoles as inhibitors of nucleases | RNASEH1, DNASE1, FEN1 | RRM1 121/4885RRM2B 17/4885ADORA3 1009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.