Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM1 | P23921 | 2/20 | 0.49 |
| ▸ | RRM2B | Q7LG56 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PHGDH | O43175 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30186382 | 0.89 | RRM1 (0.53) | RRM1RRM2BLMNAMAPTSMN1; SMN2 | |
| SCHEMBL21505894 | 0.80 | EGFR (0.43) | LMNAERN1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL3311430 | 0.75 | LMNA (0.60) | LMNAMAPTSMN1; SMN2MAPK1RAF1 | |
| SCHEMBL21495029 | 0.74 | MAPT (0.59) | LMNAMAPTSMN1; SMN2MAPK1POLB | |
| SCHEMBL28518770 | 0.74 | LMNA (0.50) | HDAC6LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL30186397 | 0.71 | RRM1 (0.50) | RRM1RRM2BLMNAMAPTSMN1; SMN2 | |
| SCHEMBL7370511 | 0.70 | ADK (0.57) | LMNAMAPTSMN1; SMN2MAPK1KMT2A | |
| SCHEMBL11476003 | 0.69 | LMNA (0.58) | LMNAMAPTSMN1; SMN2MAPK1RAF1 | |
| SCHEMBL21495070 | 0.69 | WNT3A (0.51) | LMNAMAPTSMN1; SMN2MAPK1HPGD | |
| SCHEMBL21484839 | 0.69 | MAOA (0.51) | LMNAMAPTSMN1; SMN2MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584742-B2 | Substituted aminothiazoles as inhibitors of nucleases | MASARYKOVA UNIVERZITA (CZ) | 2023-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584742-B2 | Substituted aminothiazoles as inhibitors of nucleases | RNASEH1, DNASE1, FEN1 | RRM1 121/4885RRM2B 17/4885HDAC6 2355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.