⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1355720 | 0.82 | MAPT (0.39) | — | |
| SCHEMBL27623978 | 0.80 | ALDH1A1 (0.57) | — | |
| SCHEMBL216529 | 0.78 | — | — | |
| SCHEMBL11274940 | 0.78 | — | — | |
| SCHEMBL1674254 | 0.76 | — | — | |
| SCHEMBL220742 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL10707936 | 0.76 | ALDH1A1 (0.53) | — | |
| SCHEMBL31462930 | 0.75 | ALDH1A1 (0.42) | — | |
| Hydrochloric Acid SCHEMBL28750266 | 0.74 | ALDH1A1 (0.53) | — | |
| SCHEMBL5970015 | 0.74 | ALDH1A1 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 177 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4851440-B2 | — | — | 2012-01-11 | — | — | JP | claimed |
| CN-101429194-B | Process for the preparation of tryptase inhibitors | AVENTIS PHARMACEUTICALS, INC. (US) | 2011-12-14 | — | — | CN | claimed |
| EP-1723140-B1 | PROCESS FOR THE PREPARATION OF TRYPTASE INHIBITORS | AVENTIS PHARMA INC (US) | 2009-11-04 | — | — | EP | claimed |
| CN-101429194-A | Process for the preparation of tryptase inhibitors | AVENTIS PHARMA INC (US) | 2009-05-13 | — | — | CN | claimed |
| US-20070197597-A1 | Process for the preparation of tryptase inhibitors | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-23 | — | — | US | claimed |
| CN-1950362-A | Preparation method of tryptase inhibitor | AVENTIS PHARMA INC (US) | 2007-04-18 | — | — | CN | claimed |
| EP-1723140-A1 | PROCESS FOR THE PREPARATION OF TRYPTASE INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2006-11-22 | — | — | EP | claimed |
| WO-2005095385-A1 | PROCESS FOR THE PREPARATION OF TRYPTASE INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-10-13 | — | — | WO | claimed |
| EP-1571150-A1 | Process for the preparation of tryptase inhibitors | Aventis Pharma Deutschland GmbH (DE) | 2005-09-07 | — | — | EP | claimed |
| EP-0440329-A1 | S-substituted carbonyl substituted betathioacrylamide biocides and fungicides | ROHM AND HAAS COMPANY (US) | 1991-08-07 | — | — | EP | claimed |
| CN-115626918-B | Phenyl furan-tetrahydroisoquinoline compound and preparation and application thereof | 浙江工业大学 | 2024-11-05 | — | — | CN | disclosed |
| WO-2023202583-A1 | FXR REGULATOR AND USE THEREOF | 北京大学 | 2023-10-26 | — | — | WO | disclosed |
| CN-116903559-A | FXR modulators and uses thereof | 北京大学 | 2023-10-20 | — | — | CN | disclosed |
| CN-115626918-A | Phenyl furan-tetrahydroisoquinoline compound and preparation and application thereof | 浙江工业大学 | 2023-01-20 | — | — | CN | disclosed |
| CN-112552290-B | Amido bond-containing phenylfuran-2-tetrahydroisoquinoline compound and preparation method and application thereof | 浙江工业大学 | 2022-10-11 | — | — | CN | disclosed |
| US-4344943-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1982-08-17 | — | — | US | disclosed |
| EP-0057401-A1 | Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1982-08-11 | — | — | EP | disclosed |
| US-4298616-A | FOR APPLICATION TO PLANTS OR SEEDS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-11-03 | — | — | US | disclosed |
| EP-0028465-A1 | Acylanilide compounds, methods for their preparation, compositions containing them, and processes for combatting fungi | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-05-13 | — | — | EP | disclosed |
| US-3982922-A | Herbicidal compositions containing furancarboxamides | VELSICOL CHEMICAL CORPORATION (US) | 1976-09-28 | — | — | US | disclosed |