SCHEMBL30189648

SCHEMBL30189648

FC(F)COc1cnc2c(Br)cc(Cl)cc2c1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE8A O60658 1/20 0.32
BACE1 P56817 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19783806 1.00 PDE8A (0.32) PDE8ABACE1
SCHEMBL19776340 0.82 F2RL3 (0.36) BACE1
SCHEMBL29481747 0.82 F2RL3 (0.36) BACE1
SCHEMBL19776336 0.81 KMT2A (0.37)
SCHEMBL19776056 0.77 ALDH1A1 (0.35)
SCHEMBL19776495 0.75 PDGFRB (0.47) BACE1
SCHEMBL29481777 0.75 PDGFRB (0.47) BACE1
SCHEMBL21395408 0.75 BACE1 (0.33) PDE8ABACE1
SCHEMBL30189937 0.75 BACE1 (0.33) PDE8ABACE1
SCHEMBL30460047 0.69 MBOAT4 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109689647-B Bicyclic heteroaryl substituted compounds 百时美施贵宝公司 2023-01-20 CN disclosed