Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 2/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
| ▸ | PDE8A | O60658 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21395408 | 1.00 | BACE1 (0.33) | BACE1APPBACE2LIPEAAK1 | |
| SCHEMBL29481829 | 0.86 | CTSD (0.34) | BACE1BACE2LIPE | |
| SCHEMBL19776338 | 0.86 | CTSD (0.34) | BACE1BACE2LIPE | |
| SCHEMBL29481814 | 0.85 | UCHL1 (0.34) | LIPE | |
| SCHEMBL19776254 | 0.85 | UCHL1 (0.34) | LIPE | |
| SCHEMBL29481822 | 0.83 | UCHL1 (0.35) | BACE2LIPE | |
| SCHEMBL19776055 | 0.83 | UCHL1 (0.35) | BACE2LIPE | |
| SCHEMBL30189883 | 0.77 | UCHL1 (0.35) | LIPE | |
| SCHEMBL19782702 | 0.77 | UCHL1 (0.35) | LIPE | |
| SCHEMBL30189648 | 0.75 | PDE8A (0.32) | BACE1PDE8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |