Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.43 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799569 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTTP53DYRK1ANPSR1 | |
| SCHEMBL780451 | 0.84 | RAB9A (0.61) | SMN1; SMN2MAPTTP53DYRK1AKMT2A | |
| SCHEMBL2170235 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTTP53DYRK1ANPSR1 | |
| SCHEMBL780242 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTNPSR1KMT2ALOXL2 | |
| SCHEMBL92781 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTTP53DYRK1ANPSR1 | |
| SCHEMBL9305718 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTTP53DYRK1ARAB9A | |
| Bromide SCHEMBL10996884 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTTP53DYRK1ANPSR1 | |
| SCHEMBL11549599 | 0.76 | DYRK1A (0.54) | SMN1; SMN2MAPTTP53DYRK1ARAB9A | |
| SCHEMBL2749398 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTTP53DYRK1ARAB9A | |
| SCHEMBL12262 | 0.76 | MAPT (0.72) | SMN1; SMN2MAPTTP53DYRK1ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689647-B | Bicyclic heteroaryl substituted compounds | 百时美施贵宝公司 | 2023-01-20 | — | — | CN | disclosed |