Sugi Predict

Sugi Predict / Compounds / SCHEMBL799569

SCHEMBL799569

SCHEMBL799569

Cc1ccc2sc(Cl)nc2c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 4/20 0.51
▸ MAPT P10636 2/20 0.51
▸ TP53 P04637 1/20 0.51
▸ DYRK1A Q13627 1/20 0.50
▸ NPSR1 Q6W5P4 2/20 0.47
▸ KMT2A Q03164 2/20 0.44
▸ LOXL2 Q9Y4K0 1/20 0.43
▸ IDO1 P14902 1/20 0.43
▸ RAB9A P51151 3/20 0.43
▸ PTPN7 P35236 1/20 0.43
▸ PTPN12 Q05209 1/20 0.43
▸ PTPN22 Q9Y2R2 1/20 0.43
▸ TDP1 Q9NUW8 1/20 0.42
▸ NQO2 P16083 1/20 0.41
▸ CYP1A2 P05177 1/20 0.41
▸ NPC1 O15118 2/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ LMNA P02545 2/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30189802 1.00 SMN1; SMN2 (0.51) SMN1; SMN2MAPTTP53DYRK1ANPSR1
SCHEMBL780451 0.84 RAB9A (0.61) SMN1; SMN2MAPTTP53DYRK1AKMT2A
SCHEMBL2170235 0.82 SMN1; SMN2 (0.54) SMN1; SMN2MAPTTP53DYRK1ANPSR1
SCHEMBL780242 0.81 SMN1; SMN2 (0.61) SMN1; SMN2MAPTNPSR1KMT2ALOXL2
SCHEMBL92781 0.79 SMN1; SMN2 (0.61) SMN1; SMN2MAPTTP53DYRK1ANPSR1
SCHEMBL9305718 0.78 SMN1; SMN2 (0.53) SMN1; SMN2MAPTTP53DYRK1ARAB9A
Bromide SCHEMBL10996884 0.78 SMN1; SMN2 (0.59) SMN1; SMN2MAPTTP53DYRK1ANPSR1
SCHEMBL11549599 0.76 DYRK1A (0.54) SMN1; SMN2MAPTTP53DYRK1ARAB9A
SCHEMBL2749398 0.76 SMN1; SMN2 (0.51) SMN1; SMN2MAPTTP53DYRK1ARAB9A
SCHEMBL12262 0.76 MAPT (0.72) SMN1; SMN2MAPTTP53DYRK1ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104419326-A Slurry composition for chemical mechanical polishing COWON INNOTECH INC 2015-03-18 — — CN claimed
EP-3568399-B1 AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING AGRIMETIS LLC (US) 2026-04-22 — — EP disclosed
CN-109689647-B Bicyclic heteroaryl substituted compounds 百时美施贵宝公司 2023-01-20 — — CN disclosed
EP-4001277-A2 BICYCLIC COMPOUNDS FOR DIAGNOSIS AND THERAPY AC Immune SA (CH) 2022-05-25 — — EP disclosed
US-20200148716-A1 AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING AGRIMETIS, LLC (US) 2020-05-14 — — US disclosed
US-20200148716-A1 AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING AGRIMETIS, LLC (US) 2020-05-14 — — US disclosed
US-10570165-B2 Aziridine spinosyn derivatives and methods of making AGRIMETIS, LLC (US) 2020-02-25 — — US disclosed
US-10570165-B2 Aziridine spinosyn derivatives and methods of making AGRIMETIS, LLC (US) 2020-02-25 — — US disclosed
EP-3568399-A1 AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING Agrimetis, LLC (US) 2019-11-20 — — EP disclosed
CN-109054648-A Serosity combination for chemically mechanical polishing LTCAM有限公司 2018-12-21 — — CN disclosed
US-20170136007-A1 NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF THE FEINSTEIN INST MEDICAL RES (US) 2017-05-18 — — US disclosed
US-9428522-B2 Piperazines, pharmaceutical compositions and methods of use thereof THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (US) 2016-08-30 — — US disclosed
CN-104419326-A Slurry composition for chemical mechanical polishing COWON INNOTECH INC 2015-03-18 — — CN disclosed
US-20140343059-A1 NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH 2014-11-20 — — US disclosed
US-8822472-B2 Piperazines, pharmaceutical compositions and methods of use thereof CORNERSTONE THERAPEUTICS, INC. (US) 2014-09-02 — — US disclosed
US-20120071652-A1 Novel Piperazines, Pharmaceutical Compositions and Methods of Use Thereof CORNERSTONE THERAPEUTICS, INC. (US) 2012-03-22 — — US disclosed
EP-0044008-B1 USE OF 2-PROPARGYLOXY-BENZAZOLES AS SYNERGISTS BAYER AG (DE) 1984-12-05 — — EP disclosed
EP-0043013-B1 PROCESS FOR THE PREPARATION OF 2-CHLORO-BENZOTHIAZOLES HOECHST AKTIENGESELLSCHAFT (DE) 1983-06-01 — — EP disclosed
EP-0044008-A1 Use of 2-propargyloxy-benzazoles as synergists BAYER AG (DE) 1982-01-20 — — EP disclosed
EP-0043013-A1 Process for the preparation of 2-chloro-benzothiazoles HOECHST AKTIENGESELLSCHAFT (DE) 1982-01-06 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10570165-B2 Aziridine spinosyn derivatives and methods of making AAAS, AZI2, NISCH SMN1; SMN2 404/4885MAPT 4544/4885TP53 4764/4885
US-20140343059-A1 NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF CHRNA7, CHRNA5, CHRNA2 SMN1; SMN2 782/4885MAPT 2141/4885TP53 4430/4885
US-20120071652-A1 Novel Piperazines, Pharmaceutical Compositions and Methods of Use Thereof CHRNA7, CHRNA5, CHRNA2 SMN1; SMN2 782/4885MAPT 2141/4885TP53 4430/4885
US-20200148716-A1 AZIRIDINE SPINOSYN DERIVATIVES AND METHODS OF MAKING AAAS, AZI2, NISCH SMN1; SMN2 404/4885MAPT 4544/4885TP53 4764/4885
US-20170136007-A1 NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF CHRNA7, CHRNA5, CHRM5 SMN1; SMN2 468/4885MAPT 3014/4885TP53 3811/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.