SCHEMBL30193015

NC(=O)CC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CCC(=O)O)C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	BACE1	P56817	16/20	0.53

▸	CTSD	P07339	2/20	0.49

▸	BACE2	Q9Y5Z0	2/20	0.48

▸	NAALAD2	Q9Y3Q0	1/20	0.47

▸	OPRM1	P35372	1/20	0.47

▸	OPRD1	P41143	1/20	0.47

▸	OPRK1	P41145	1/20	0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL29470277	0.99	BACE1 (0.55)	BACE1CTSDBACE2OPRM1OPRD1
SCHEMBL29383336	0.97	BACE1 (0.56)	BACE1CTSDBACE2NAALAD2OPRM1
SCHEMBL29590401	0.96	BACE1 (0.51)	BACE1CTSDBACE2NAALAD2OPRM1
SCHEMBL31031476	0.92	BACE1 (0.54)	BACE1CTSDBACE2NAALAD2OPRM1
SCHEMBL30987807	0.92	BACE1 (0.53)	BACE1CTSDBACE2NAALAD2OPRM1
SCHEMBL29630643	0.91	OPRM1 (0.51)	BACE1CTSDBACE2NAALAD2OPRM1
SCHEMBL29695521	0.90	BACE1 (0.52)	BACE1CTSDNAALAD2OPRM1OPRD1
SCHEMBL29431016	0.89	PTGS1 (0.44)	BACE1CTSDNAALAD2
SCHEMBL31031528	0.89	NAALAD2 (0.55)	BACE1CTSDBACE2NAALAD2OPRM1
SCHEMBL29814935	0.88	GLO1 (0.43)	BACE1CTSDBACE2NAALAD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-4367144-A1	INTERLEUKIN-1 ALPHA CHIMERIC PROTEIN	Orionis Biosciences, Inc. (US)	2024-05-15	—	—	EP	disclosed
WO-2023283638-A1	INTERLEUKIN-1 ALPHA CHIMERIC PROTEIN	ORIONIS BIOSCIENCES, INC. (US)	2023-01-12	—	—	WO	disclosed