Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 2/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14857825 | 0.84 | PDE8B (0.39) | PKMLMNABRD4EEDRBBP4 | |
| SCHEMBL19222887 | 0.81 | PKM (0.49) | PKMLMNANPBWR1PDE1APDE1B | |
| SCHEMBL14857868 | 0.79 | PKM (0.44) | PKMLMNANPBWR1PDE1APDE1B | |
| SCHEMBL17459025 | 0.78 | PKM (0.54) | PKMLMNANPBWR1PDE1APDE1B | |
| SCHEMBL6156218 | 0.76 | PKM (0.48) | PKMLMNANPBWR1PDE1APDE1B | |
| SCHEMBL18256013 | 0.74 | CRHR1 (0.46) | PKMLMNANPBWR1PDE1APDE1B | |
| SCHEMBL19170534 | 0.72 | LMNA (0.47) | PKMLMNANPBWR1PDE1APDE1B | |
| SCHEMBL17458967 | 0.72 | LMNA (0.44) | PKMLMNANPBWR1PDE1APDE1B | |
| SCHEMBL17076641 | 0.71 | PKM (0.43) | PKMLMNANPBWR1NPSR1MEN1 | |
| SCHEMBL26692283 | 0.71 | LMNA (0.37) | PKMLMNANPBWR1PDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4401729-A1 | BCL-XL DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-24 | — | — | EP | disclosed |
| WO-2023044046-A1 | BCL-XL DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-23 | — | — | WO | disclosed |