Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68581 | 0.83 | MEN1 (0.61) | MEN1ALDH1A1HPGDKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL5512697 | 0.82 | MEN1 (0.59) | MEN1ALDH1A1HPGDKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL29473284 | 0.82 | MEN1 (0.59) | MEN1ALDH1A1HPGDKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL7142299 | 0.82 | MEN1 (0.59) | MEN1ALDH1A1HPGDKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL30205268 | 0.80 | MEN1 (0.58) | MEN1ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL641073 | 0.73 | MEN1 (0.49) | MEN1ALDH1A1HPGDKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL6137124 | 0.72 | MEN1 (0.47) | MEN1ALDH1A1HPGDKMT2AMAPT | |
| Tert-Butyl Formate SCHEMBL27766278 | 0.72 | MEN1 (0.46) | MEN1ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL27303153 | 0.71 | ALDH1A1 (0.51) | MEN1ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL25562136 | 0.69 | MAPT (0.42) | MEN1ALDH1A1HPGDKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115710268-A | Crystalline form of fused heterocyclic compound derivative hydrochloride and preparation method thereof | 江苏恩华药业股份有限公司 | 2023-02-24 | — | — | CN | disclosed |