Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206357 | 0.78 | ALDH1A1 (0.45) | CYP2D6TSHRSLC6A2SLC6A4HTT | |
| SCHEMBL2640938 | 0.74 | ALDH1A1 (0.42) | LMNACYP1A2CHRM2CHRM4CHRM5 | |
| SCHEMBL4753616 | 0.69 | KDM4E (0.44) | CYP1A2CHRM2CHRM4CHRM5ADRA2A | |
| SCHEMBL15399051 | 0.68 | KDM4E (0.41) | LMNACHRM4TSHRCHRM3HTT | |
| SCHEMBL1405661 | 0.67 | LTA4H (0.85) | LMNACYP1A2CHRM2CHRM4CHRM5 | |
| SCHEMBL17208188 | 0.66 | — | — | |
| SCHEMBL4126571 | 0.66 | TAAR1 (0.50) | TSHRHTR2AHRH1HTTSMN1; SMN2 | |
| SCHEMBL11501576 | 0.66 | TAAR1 (0.50) | LMNACHRM2ADRA2ATSHRADRA2B | |
| Bromide SCHEMBL1174583 | 0.65 | LTA4H (0.81) | LMNACYP1A2CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL10682691 | 0.65 | LTA4H (0.81) | CYP1A2CHRM2CHRM4CHRM5ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |