Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 4/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29173611 | 1.00 | EGFR (0.40) | EGFRSRCFGFR1ABL1BCR | |
| SCHEMBL29173539 | 0.93 | SYK (0.41) | EGFRSRCFGFR1ABL1BCR | |
| SCHEMBL24944757 | 0.93 | TBK1 (0.42) | EGFRSRCFGFR1ABL1BCR | |
| SCHEMBL29173422 | 0.91 | TNIK (0.39) | SRCFGFR1SYKCDK1KDR | |
| SCHEMBL29173415 | 0.90 | CCNC (0.42) | EGFRSYKSMN1; SMN2 | |
| SCHEMBL30206202 | 0.88 | PKMYT1 (0.40) | ABL1SYKJAK2CDK1KDR | |
| SCHEMBL29173512 | 0.88 | PKMYT1 (0.40) | ABL1SYKJAK2CDK1KDR | |
| SCHEMBL30206169 | 0.88 | SYK (0.36) | EGFRABL1BCRSYKJAK2 | |
| SCHEMBL30206043 | 0.88 | SYK (0.32) | EGFRABL1BCRSYKJAK2 | |
| SCHEMBL29173540 | 0.88 | SYK (0.36) | EGFRABL1BCRSYKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2024-05-29 | — | — | EP | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |