Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206221 | 0.93 | EGFR (0.40) | SYKEGFRSRCFGFR1JAK2 | |
| SCHEMBL29173611 | 0.93 | EGFR (0.40) | SYKEGFRSRCFGFR1JAK2 | |
| SCHEMBL24944757 | 0.93 | TBK1 (0.42) | SYKEGFRSRCFGFR1KDM4E | |
| SCHEMBL29173582 | 0.87 | PIM1 (0.41) | SYKJAK2KDRABL1 | |
| SCHEMBL30206281 | 0.86 | HRH3 (0.37) | SYK | |
| SCHEMBL29173651 | 0.86 | HRH3 (0.37) | SYK | |
| SCHEMBL29173422 | 0.84 | TNIK (0.39) | SYKSRCFGFR1CDK1KDR | |
| SCHEMBL30205550 | 0.83 | CAMK2D (0.40) | SYKFGFR1CDK1KDR | |
| SCHEMBL24944792 | 0.83 | CAMK2D (0.40) | SYKFGFR1CDK1KDR | |
| SCHEMBL29173415 | 0.83 | CCNC (0.42) | SYKEGFRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |