Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | CASP9 | P55211 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206281 | 0.88 | HRH3 (0.37) | HRH3CCNCCDK8SYKFGFR3 | |
| SCHEMBL29173651 | 0.88 | HRH3 (0.37) | HRH3CCNCCDK8SYKFGFR3 | |
| SCHEMBL24943841 | 0.82 | SYK (0.38) | HRH3CCNCCDK8SYKAXL | |
| SCHEMBL29173450 | 0.81 | FGFR3 (0.39) | HRH3CCNCCDK8MAPK14SYK | |
| SCHEMBL30206332 | 0.81 | FGFR3 (0.39) | HRH3CCNCCDK8MAPK14SYK | |
| Formic Acid SCHEMBL30205745 | 0.80 | SYK (0.36) | HRH3CCNCCDK8SYKAXL | |
| Formic Acid SCHEMBL29173273 | 0.80 | SYK (0.36) | HRH3CCNCCDK8SYKAXL | |
| SCHEMBL30206132 | 0.79 | LRRK2 (0.36) | CCNCCDK8KCNH2SYKEGFR | |
| SCHEMBL29173704 | 0.79 | LRRK2 (0.36) | CCNCCDK8KCNH2SYKEGFR | |
| SCHEMBL29173539 | 0.78 | SYK (0.41) | SYKSRCABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4373817-B1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2025-05-21 | — | — | EP | disclosed |