Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAM | P19021 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.48 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6064354 | 1.00 | PAM (0.59) | PAMHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL28158290 | 0.93 | PAM (0.52) | PAMHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL29067636 | 0.90 | PAM (0.53) | PAMHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL11155173 | 0.89 | GPR52 (0.50) | PAMHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL2308813 | 0.89 | PAM (0.52) | PAMHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL2308808 | 0.89 | PAM (0.52) | PAMHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL7112361 | 0.88 | PAM (0.55) | PAMHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL666894 | 0.88 | PAM (0.64) | PAMHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL1231739 | 0.88 | PAM (0.64) | PAMHDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL1232837 | 0.88 | PAM (0.64) | PAMHDAC3HDAC4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130273798-A1 | ANTI-ALLERGEN AGENT | TOAGOSEI CO., LTD. (JP) | 2013-10-17 | — | — | US | disclosed |
| US-20100209530-A1 | ANTI-ALLERGEN AGENT | TOAGOSEI CO., LTD. (JP) | 2010-08-19 | — | — | US | disclosed |
| EP-1754700-A2 | Synthesis of oligoketides | Kosan Biosciences, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| US-7022825-B2 | Polyketides and antibiotics | KOSAN BIOSCIENCES, INC. (US) | 2006-04-04 | — | — | US | disclosed |
| EP-1471923-A4 | AMIDO MACROLIDES | KOSAN BIOSCIENCES INC (US) | 2006-01-11 | — | — | EP | disclosed |
| US-6939861-B2 | Amido macrolides | KOSAN BIOSCIENCES, INC. (US) | 2005-09-06 | — | — | US | disclosed |
| EP-1471923-A1 | AMIDO MACROLIDES | Kosan Biosciences, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| US-20030199458-A1 | Amido macrolides | KOSAN BIOSCIENCES, INC. | 2003-10-23 | — | — | US | disclosed |
| EP-0794218-B1 | Polycarbonate resin composition stabilized against radiation | MITSUBISHI ENG PLASTICS CORP (JP) | 2003-10-15 | — | — | EP | disclosed |
| WO-2003061671-A1 | AMIDO MACROLIDES | KOSAN BIOSCIENCES, INC. (US) | 2003-07-31 | — | — | WO | disclosed |
| US-20030092140-A1 | Novel polyketides and antibiotics | ASHLEY GARY (US) | 2003-05-15 | — | — | US | disclosed |
| EP-1144375-A2 | SYNTHESIS OF OLIGOKETIDES | Kosan Biosciences (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000044717-A9 | SYNTHESIS OF OLIGOKETIDES | — | 2001-08-23 | — | — | WO | disclosed |
| WO-2000044717-A2 | SYNTHESIS OF OLIGOKETIDES | KOSAN BIOSCIENCES, INC. (US) | 2000-08-03 | — | — | WO | disclosed |
| US-6040367-A | EXCELLENT RESISTANCE TO AN IONIZING RADIATION, IN WHICH HETEROCYCLIC COMPOUND CONTAINING OXYMETHYLENE UNITS | MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) | 2000-03-21 | — | — | US | disclosed |
| US-5948838-A | 0.01 TO 5 PARTS BY WEIGHT OF A COMPOUND CONTAINING OXYMETHYLENE UNIT | MITSUBISHI ENGINEERING-PLASTICS CORP. (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0794218-A2 | Polycarbonate resin composition stabilized against radiation | MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) | 1997-09-10 | — | — | EP | disclosed |
| US-5360775-A | Porous clay intercalation compound and its production method | MITSUBISHI MATERIAL CORPORATION (JP) | 1994-11-01 | — | — | US | disclosed |
| US-5013709-A | Acid-treated smectite clay mineral | MIZUSAWA INDUSTRIAL CHEMICALS, LTD. (JP) | 1991-05-07 | — | — | US | disclosed |
| US-4709024-A | REARRANGEMENT OF CYCLOHEXANONE OXIME | SUMITOMO CHEMICAL COMPANY (JP) | 1987-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199458-A1 | Amido macrolides | PCSK9, ABCB4, PCSK7 | PAM 73/4885HDAC3 221/4885HDAC4 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.