Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | HTR2C | P28335 | 6/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304038 | 0.83 | NPC1 (0.42) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL302050 | 0.81 | HTR2C (0.53) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL1976235 | 0.78 | CNR2 (0.44) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL302209 | 0.77 | CNR2 (0.51) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL301830 | 0.75 | HTR2C (0.61) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL2188016 | 0.75 | KDM4E (0.43) | LMNAPOLBPKMHTTNPC1 | |
| SCHEMBL301863 | 0.74 | MEN1 (0.49) | SMN1; SMN2NPC1 | |
| SCHEMBL3281350 | 0.74 | HTR2C (0.53) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL1966404 | 0.73 | DRD4 (0.51) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL3275347 | 0.72 | HTR2C (0.54) | CNR2HTR2CHTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500835-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2334637-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-06-22 | — | — | EP | claimed |
| EP-2334637-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-06-22 | — | — | EP | disclosed |