Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 6/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 13/20 | 0.48 |
| ▸ | CDC42BPB | Q9Y5S2 | 13/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 12/20 | 0.48 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.48 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30208810 | 0.82 | MAPK1 (0.72) | MAPK1ROCK1CDC42BPBROCK2CDC42BPA | |
| SCHEMBL30208793 | 0.76 | MAPK1 (0.51) | MAPK1ROCK1ROCK2 | |
| SCHEMBL29572525 | 0.74 | MAPK1 (0.49) | MAPK1HASPIN | |
| SCHEMBL29869781 | 0.74 | TGFBR1 (0.60) | ROCK1ROCK2HASPIN | |
| SCHEMBL24672968 | 0.73 | ROCK1 (0.58) | ROCK1CDC42BPBROCK2CDC42BPA | |
| SCHEMBL30668767 | 0.73 | ROCK1 (0.57) | ROCK1CDC42BPBROCK2CDC42BPA | |
| SCHEMBL968641 | 0.71 | CDC7 (0.50) | MAPK1ROCK1ROCK2CDC42BPA | |
| SCHEMBL935536 | 0.66 | CDC7 (0.65) | MAPK1ROCK1ROCK2CDC42BPA | |
| SCHEMBL24672457 | 0.66 | ROCK1 (1.00) | ROCK1CDC42BPBROCK2CDC42BPA | |
| SCHEMBL12482657 | 0.66 | MAPK1 (0.44) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250134869-A1 | Pyrrolo[2,3-d]pyrimidinyl, Pyrrolo[2,3-b]pyrazinyl and Pyrrolo[2,3-d]pyridinyl Acryla-mides | PFIZER INC (US) | 2025-05-01 | — | — | US | disclosed |
| US-12077533-B2 | Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides | PFIZER INC. (US) | 2024-09-03 | — | — | US | disclosed |
| US-20230009153-A1 | PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYRROLO[2,3-D]PYRIDINYL ACRYLAMIDES | PFIZER INC. (US) | 2023-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12077533-B2 | Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides | ACR, PKD2, PGA5 | MAPK1 2289/4885ROCK1 4332/4885CDC42BPB 2448/4885 |
| US-20250134869-A1 | Pyrrolo[2,3-d]pyrimidinyl, Pyrrolo[2,3-b]pyrazinyl and Pyrrolo[2,3-d]pyridinyl Acryla-mides | JAK2, JAK3, JAK1 | MAPK1 232/4885ROCK1 988/4885CDC42BPB 1171/4885 |
| US-20230009153-A1 | PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYRROLO[2,3-D]PYRIDINYL ACRYLAMIDES | JAK2, JAK3, JAK1 | MAPK1 278/4885ROCK1 1111/4885CDC42BPB 956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.