Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24070455 | 1.00 | HTT (0.57) | HTTSRD5A2MAPTRAB9ANPC1 | |
| SCHEMBL2616496 | 0.82 | RECQL (0.51) | HTTMAPTALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL9377446 | 0.77 | ALDH1A1 (0.49) | HTTMAPTRAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL9496067 | 0.76 | SRD5A2 (0.79) | HTTSRD5A2MAPTRAB9ANPC1 | |
| SCHEMBL9822900 | 0.76 | SRD5A2 (0.58) | HTTSRD5A2MAPTRAB9ANPC1 | |
| SCHEMBL30185351 | 0.75 | SMN1; SMN2 (0.71) | HTTSRD5A2MAPTRAB9AALDH1A1 | |
| SCHEMBL195020 | 0.75 | SMN1; SMN2 (0.71) | HTTSRD5A2MAPTRAB9AALDH1A1 | |
| SCHEMBL10633292 | 0.73 | SRD5A2 (0.59) | HTTSRD5A2MAPTRAB9ANPC1 | |
| SCHEMBL27535758 | 0.73 | ALDH1A1 (0.53) | HTTALDH1A1 | |
| SCHEMBL522683 | 0.73 | SRD5A2 (0.74) | HTTSRD5A2MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115867535-B | Substituted benzamides as modulators of TREX1 | 星座制药公司 | 2024-12-17 | — | — | CN | disclosed |
| CN-115867535-A | Substituted benzamides as modulators of TREX1 | 星座制药公司 | 2023-03-28 | — | — | CN | disclosed |