Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23930542 | 0.96 | KDM4E (0.59) | LMNAKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL30210844 | 0.91 | DHODH (0.53) | LMNAKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL30210901 | 0.91 | KDM4E (0.55) | LMNAKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL23930511 | 0.90 | CCNA2 (0.60) | LMNAMAPTMEN1KMT2APOLB | |
| SCHEMBL31633449 | 0.88 | DHODH (0.56) | LMNAKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL23930620 | 0.88 | DHODH (0.56) | LMNAKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL4486366 | 0.87 | MEN1 (0.60) | LMNAKDM4EMAPTMEN1KMT2A | |
| SCHEMBL4478262 | 0.86 | MAPT (0.54) | LMNAKDM4EMAPTMEN1KMT2A | |
| SCHEMBL30210843 | 0.85 | KDM4E (0.47) | LMNAKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL3819003 | 0.84 | RAB9A (0.57) | LMNAKDM4EALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139287-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | Bayer Aktiengesellschaft (DE) | 2023-03-01 | — | — | EP | disclosed |