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SCHEMBL4478262

SCHEMBL4478262

CCOC(=O)c1cc(C(=O)c2sc(Nc3ccc(Oc4ccccc4)cc3)nc2N)on1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.54
▸ TP53 P04637 1/20 0.54
▸ RXFP1 Q9HBX9 1/20 0.54
▸ ZAP70 P43403 1/20 0.53
▸ DHODH Q02127 8/20 0.52
▸ MEN1 O00255 3/20 0.51
▸ KMT2A Q03164 3/20 0.51
▸ CDK5 Q00535 3/20 0.51
▸ CDK5R1 Q15078 3/20 0.51
▸ LMNA P02545 1/20 0.51
▸ CCNA2 P20248 3/20 0.51
▸ CDK2 P24941 3/20 0.51
▸ NPC1 O15118 3/20 0.49
▸ RAB9A P51151 2/20 0.49
▸ HPGD P15428 1/20 0.49
▸ KDM4E B2RXH2 1/20 0.47
▸ GSK3A P49840 1/20 0.47
▸ GSK3B P49841 1/20 0.47
▸ MAPK14 Q16539 1/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4486366 0.91 MEN1 (0.60) MAPTTP53RXFP1ZAP70DHODH
SCHEMBL23930542 0.87 KDM4E (0.59) MAPTTP53RXFP1ZAP70DHODH
SCHEMBL30210871 0.86 LMNA (0.55) MAPTTP53RXFP1ZAP70DHODH
SCHEMBL31633449 0.84 DHODH (0.56) MAPTTP53RXFP1ZAP70DHODH
SCHEMBL23930620 0.84 DHODH (0.56) MAPTTP53RXFP1ZAP70DHODH
SCHEMBL30210844 0.83 DHODH (0.53) MAPTTP53RXFP1DHODHMEN1
SCHEMBL13633840 0.83 CDK5 (0.53) MAPTTP53RXFP1ZAP70MEN1
SCHEMBL3819003 0.82 RAB9A (0.57) MAPTTP53RXFP1DHODHMEN1
SCHEMBL30210901 0.82 KDM4E (0.55) MAPTTP53RXFP1ZAP70DHODH
SCHEMBL4471723 0.78 CCNA2 (0.46) MAPTDHODHCDK5CDK5R1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US claimed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-8470821-B2 PDE4B inhibitors and uses therefor PLEXXIKON INC. (US) 2013-06-25 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PLEXXIKON, INC. 2009-11-19 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-7585859-B2 PDE4B inhibitors and uses therefor PLEXXIKON, INC. (US) 2009-09-08 — — US disclosed
US-20060041006-A1 PDE4B inhibitors and uses therefor PLEXXIKON, INC. 2006-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286793-A1 PDE4B INHIBITORS AND USES THEREFOR PDE4B, PDE7B, PDE4A MAPT 3524/4885TP53 4190/4885RXFP1 582/4885
US-20060041006-A1 PDE4B inhibitors and uses therefor PDE4B, PDE7B, PDE4A MAPT 3524/4885TP53 4190/4885RXFP1 582/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.