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SCHEMBL23930542

SCHEMBL23930542

CCOC(=O)c1cc(C(=O)c2sc(Nc3ccc(F)cc3)nc2N)on1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.59
▸ LMNA P02545 2/20 0.59
▸ ALDH1A1 P00352 1/20 0.59
▸ MAPT P10636 6/20 0.56
▸ MEN1 O00255 4/20 0.56
▸ KMT2A Q03164 4/20 0.56
▸ POLB P06746 1/20 0.56
▸ DHODH Q02127 4/20 0.56
▸ TP53 P04637 3/20 0.56
▸ NPC1 O15118 3/20 0.55
▸ CCNA2 P20248 2/20 0.51
▸ CDK2 P24941 2/20 0.51
▸ CDK5 Q00535 3/20 0.50
▸ CDK5R1 Q15078 3/20 0.50
▸ RXFP1 Q9HBX9 1/20 0.48
▸ ZAP70 P43403 1/20 0.47
▸ HPGD P15428 1/20 0.46
▸ NFKB1 P19838 1/20 0.46
▸ RAB9A P51151 1/20 0.46
▸ NFKB2 Q00653 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30210871 0.96 LMNA (0.55) KDM4ELMNAALDH1A1MAPTMEN1
SCHEMBL30210901 0.94 KDM4E (0.55) KDM4ELMNAALDH1A1MAPTMEN1
SCHEMBL31633449 0.91 DHODH (0.56) KDM4ELMNAALDH1A1MAPTMEN1
SCHEMBL23930620 0.91 DHODH (0.56) KDM4ELMNAALDH1A1MAPTMEN1
SCHEMBL4486366 0.91 MEN1 (0.60) KDM4ELMNAMAPTMEN1KMT2A
SCHEMBL30210843 0.88 KDM4E (0.47) KDM4ELMNAALDH1A1MAPTMEN1
SCHEMBL30210844 0.88 DHODH (0.53) KDM4ELMNAALDH1A1MAPTMEN1
SCHEMBL4478262 0.87 MAPT (0.54) KDM4ELMNAMAPTMEN1KMT2A
SCHEMBL3819003 0.85 RAB9A (0.57) KDM4ELMNAALDH1A1MAPTMEN1
SCHEMBL23930511 0.85 CCNA2 (0.60) LMNAMAPTMEN1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115697979-B Substituted aminothiazoles as DGKZETA inhibitors for immune activation 拜耳公司 2025-06-24 — — CN disclosed
EP-4139287-B1 SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION BAYER AG (DE) 2025-02-26 — — EP disclosed
US-20230167103-A1 SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION BAYER AKTIENGESELLSCHAFT (DE) 2023-06-01 — — US disclosed
US-20230167103-A1 SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION BAYER AKTIENGESELLSCHAFT (DE) 2023-06-01 — — US disclosed
US-20230167103-A1 SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION BAYER AKTIENGESELLSCHAFT (DE) 2023-06-01 — — US disclosed
EP-4139287-A1 SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION Bayer Aktiengesellschaft (DE) 2023-03-01 — — EP disclosed
CN-115697979-A Substituted aminothiazoles as DGKZETA inhibitors for immune activation 拜耳公司 2023-02-03 — — CN disclosed
WO-2021214020-A1 SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION BAYER AKTIENGESELLSCHAFT (DE) 2021-10-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230167103-A1 SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION DGKZ, DGKA, DGKG KDM4E 1128/4885LMNA 3883/4885ALDH1A1 3965/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.