Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 6/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24898687 | 1.00 | MAPT (0.36) | MAPTABCG2KMT2ABRAFGRIN1 | |
| SCHEMBL10285831 | 0.85 | GRIN1 (0.47) | MAPTGRIN1HSD17B10PGRDAO | |
| SCHEMBL23269912 | 0.83 | MAPT (0.44) | MAPTABCG2KMT2AGRIN1HSD17B10 | |
| SCHEMBL2418890 | 0.81 | CACNA1H (0.41) | MAPTABCG2KMT2A | |
| SCHEMBL2420442 | 0.80 | GRIN1 (0.42) | MAPTABCG2KMT2ABRAFGRIN1 | |
| SCHEMBL2417841 | 0.80 | RIPK1 (0.37) | MAPTABCG2KMT2ABRAFGRIN1 | |
| SCHEMBL2419588 | 0.80 | BRAF (0.35) | MAPTABCG2KMT2ABRAFGRIN1 | |
| SCHEMBL2419473 | 0.80 | ALDH1A1 (0.38) | MAPTABCG2KMT2ABRAFGRIN1 | |
| SCHEMBL2420853 | 0.79 | PDE3B (0.35) | MAPTBRAFCA12CA9PDE3B | |
| SCHEMBL13759408 | 0.77 | ABCG2 (0.33) | MAPTABCG2KMT2ABRAFGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023288242-A1 | PI3Kα INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2023-01-19 | — | — | WO | disclosed |