SCHEMBL2418890

SCHEMBL2418890

O=c1[nH]c2cc(C(F)(F)F)cc(C(F)(F)F)c2[nH]1

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CACNA1H O95180 11/20 0.41
CACNA1C Q13936 3/20 0.41
CACNA1B Q00975 3/20 0.41
GPR17 Q13304 1/20 0.38
CACNA1G O43497 4/20 0.37
EGLN1 Q9GZT9 1/20 0.36
MAPT P10636 1/20 0.36
ABCG2 Q9UNQ0 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22169013 0.88 KIF11 (0.40) CACNA1HCACNA1CCACNA1BCACNA1GMAPT
SCHEMBL7779818 0.85 GRIN1 (0.46) CACNA1HCACNA1CCACNA1BGPR17CACNA1G
SCHEMBL23269912 0.83 MAPT (0.44) MAPTABCG2KMT2A
SCHEMBL8873491 0.82 GRIN1 (0.41) CACNA1HCACNA1CCACNA1BGPR17CACNA1G
SCHEMBL30211489 0.81 MAPT (0.36) MAPTABCG2KMT2A
SCHEMBL24898687 0.81 MAPT (0.36) MAPTABCG2KMT2A
SCHEMBL2420442 0.80 GRIN1 (0.42) EGLN1MAPTABCG2KMT2A
SCHEMBL2417841 0.80 RIPK1 (0.37) EGLN1MAPTABCG2KMT2A
SCHEMBL2419473 0.80 ALDH1A1 (0.38) MAPTABCG2KMT2A
SCHEMBL2419588 0.80 BRAF (0.35) MAPTABCG2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260042743-A1 SUBSTITUTED BENZIMIDAZOLES FOR TREATING VIRAL DISEASES COUNCIL SCIENT IND RES (IN) 2026-02-12 US disclosed
US-8026241-B2 Vanilloid receptor ligands and their use in treatments AMGEN INC. (US) 2011-09-27 US disclosed
US-7582761-B2 Vanilloid receptor ligands and their use in treatments AMGEN INC. (US) 2009-09-01 US disclosed
US-20090143575-A1 VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS BALAN CHENERA 2009-06-04 US disclosed
US-20040152690-A1 Vanilloid receptor ligands and their use in treatments AMGEN INC. 2004-08-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090143575-A1 VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS TRPV1, TRPV3, TRPV2 CACNA1H 558/4885CACNA1C 485/4885CACNA1B 458/4885
US-20040152690-A1 Vanilloid receptor ligands and their use in treatments TRPV1, TRPV3, TRPV2 CACNA1H 532/4885CACNA1C 453/4885CACNA1B 519/4885
US-20260042743-A1 SUBSTITUTED BENZIMIDAZOLES FOR TREATING VIRAL DISEASES ACE2, SARS1, NR3C2 CACNA1H 1849/4885CACNA1C 1701/4885CACNA1B 643/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.