SCHEMBL30212166

SCHEMBL30212166

CCOC(=O)CC(=O)c1c(F)ccc(Br)c1F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.40
MGAM O43451 1/20 0.40
SI P14410 1/20 0.40
MGAM2 Q2M2H8 1/20 0.40
NLRP3 Q96P20 1/20 0.40
KMT2A Q03164 6/20 0.38
MEN1 O00255 5/20 0.38
ALDH1A1 P00352 3/20 0.38
KDM4E B2RXH2 2/20 0.38
MAPT P10636 6/20 0.38
HPGD P15428 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.36
TSHR P16473 1/20 0.35
IDO1 P14902 1/20 0.35
NPSR1 Q6W5P4 3/20 0.35
TP53 P04637 1/20 0.35
HTT P42858 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
MIF P14174 1/20 0.34
TRPA1 O75762 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24047677 1.00 GAA (0.40) GAAMGAMSIMGAM2NLRP3
SCHEMBL1555531 0.88 MGAM (0.45) GAAMGAMSIMGAM2NLRP3
SCHEMBL25204360 0.82 NLRP3 (0.49) GAAMGAMSIMGAM2NLRP3
SCHEMBL28706649 0.81 CA12 (0.47) GAAKMT2AMEN1ALDH1A1MAPT
SCHEMBL7501566 0.81 MGAM (0.41) GAAMGAMSIMGAM2NLRP3
SCHEMBL27705854 0.80 ALDH1A1 (0.49) GAAMGAMSIMGAM2KMT2A
SCHEMBL1931504 0.80 NLRP3 (0.55) GAAMGAMSIMGAM2NLRP3
SCHEMBL9263418 0.77 ALDH1A1 (0.44) GAAMGAMSIMGAM2NLRP3
SCHEMBL7863801 0.77 ALDH1A1 (0.44) GAAMGAMSIMGAM2NLRP3
SCHEMBL7504653 0.77 ALDH1A1 (0.41) GAAMGAMSIMGAM2NLRP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115697975-A Herbicidal cinnoline derivatives 先正达农作物保护股份公司 2023-02-03 CN disclosed