SCHEMBL30213434

SCHEMBL30213434

O=C1CCC(N2Cc3ccc(NC(=O)c4ccccc4OCC4CNC4)cc3C2=O)C(=O)N1

nearest known ligand 0.56

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 20/20 0.56
CSNK1A1 P48729 10/20 0.56
IKZF2 Q9UKS7 8/20 0.48
GSPT1 P15170 3/20 0.48
IKZF3 Q9UKT9 2/20 0.45
DDB1 Q16531 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30213320 0.94 CRBN (0.65) CRBNCSNK1A1IKZF2GSPT1IKZF3
SCHEMBL30213435 0.86 CRBN (0.62) CRBNCSNK1A1IKZF2GSPT1DDB1
SCHEMBL29126562 0.86 CRBN (0.60) CRBNCSNK1A1IKZF2GSPT1IKZF3
SCHEMBL30213409 0.82 CRBN (0.68) CRBNCSNK1A1IKZF2GSPT1IKZF3
SCHEMBL30213383 0.80 CRBN (0.47) CRBNCSNK1A1IKZF2GSPT1IKZF3
SCHEMBL30213362 0.80 CRBN (0.85) CRBNCSNK1A1IKZF2GSPT1DDB1
SCHEMBL30213232 0.80 CRBN (0.73) CRBNCSNK1A1IKZF2GSPT1IKZF3
SCHEMBL24078678 0.79 CRBN (0.70) CRBNCSNK1A1IKZF2GSPT1IKZF3
SCHEMBL30213319 0.78 CRBN (0.69) CRBNCSNK1A1IKZF2
SCHEMBL23534534 0.76 CRBN (0.68) CRBNCSNK1A1IKZF2GSPT1IKZF3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115768768-A Galectin-3 inhibitors 百时美施贵宝公司 2023-03-07 CN disclosed