Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 6/20 | 0.57 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CCNK | O75909 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | GOT1 | P17174 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30214209 | 0.85 | KAT2B (0.46) | KAT2BNLRP3EGFRCHEK1BPTF | |
| SCHEMBL30101084 | 0.84 | NLRP3 (0.54) | KAT2BNLRP3EGFRBPTF | |
| SCHEMBL30101116 | 0.84 | NLRP3 (0.54) | KAT2BNLRP3EGFRBPTF | |
| SCHEMBL29131917 | 0.84 | CAMK2D (0.47) | KAT2BNLRP3KDM4EHSD17B10LMNA | |
| SCHEMBL30101129 | 0.83 | NLRP3 (0.55) | KAT2BNLRP3CHEK2KDM4EHSD17B10 | |
| SCHEMBL30101066 | 0.82 | KAT2B (0.46) | KAT2BNLRP3EGFRBPTF | |
| SCHEMBL30101025 | 0.80 | IL1B (0.44) | KAT2BNLRP3KDM4EHSD17B10LMNA | |
| SCHEMBL24574981 | 0.79 | KAT2B (0.61) | KAT2BNLRP3CHEK2KDM4EHSD17B10 | |
| SCHEMBL30038747 | 0.79 | KAT2B (0.61) | KAT2BNLRP3CHEK2KDM4EHSD17B10 | |
| SCHEMBL26110981 | 0.79 | KAT2B (0.61) | KAT2BNLRP3CHEK2KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4392414-A1 | INHIBITORS OF NLRP3 | PTC Therapeutics, Inc. (US) | 2024-07-03 | — | — | EP | claimed |
| WO-2023028534-A1 | INHIBITORS OF NLRP3 | PTC THERAPEUTICS, INC. (US) | 2023-03-02 | — | — | WO | claimed |
| EP-4392414-A1 | INHIBITORS OF NLRP3 | PTC Therapeutics, Inc. (US) | 2024-07-03 | — | — | EP | disclosed |
| WO-2023028534-A1 | INHIBITORS OF NLRP3 | PTC THERAPEUTICS, INC. (US) | 2023-03-02 | — | — | WO | disclosed |