Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4500841 | 0.78 | P2RX7 (0.59) | P2RX7ALDH1A1 | |
| SCHEMBL14943853 | 0.77 | P2RX7 (0.61) | P2RX7ADORA2AALDH1A1 | |
| SCHEMBL13238442 | 0.76 | P2RX7 (0.51) | P2RX7ADORA2ACA2ALDH1A1 | |
| SCHEMBL3745242 | 0.75 | P2RX7 (0.51) | P2RX7ADORA2AALDH1A1 | |
| SCHEMBL6084856 | 0.74 | P2RX7 (0.58) | P2RX7 | |
| SCHEMBL31424200 | 0.74 | P2RX7 (0.76) | P2RX7 | |
| SCHEMBL3730219 | 0.73 | P2RX7 (0.56) | P2RX7CA2EPHX2 | |
| SCHEMBL3454922 | 0.73 | P2RX7 (1.00) | P2RX7CA2EPHX2 | |
| SCHEMBL7571057 | 0.73 | P2RX7 (1.00) | P2RX7CA2 | |
| SCHEMBL7570195 | 0.73 | P2RX7 (1.00) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2096923-B1 | HETEROARYL AMIDE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2014-01-22 | — | — | EP | disclosed |
| EP-2096923-B1 | HETEROARYL AMIDE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2014-01-22 | — | — | EP | disclosed |
| US-20130172549-A1 | Heteroaryl amide derivatives | H. LUNDBECK A/S (DK) | 2013-07-04 | — | — | US | disclosed |
| US-20130172549-A1 | Heteroaryl amide derivatives | H. LUNDBECK A/S (DK) | 2013-07-04 | — | — | US | disclosed |
| US-20130172549-A1 | Heteroaryl amide derivatives | H. LUNDBECK A/S (DK) | 2013-07-04 | — | — | US | disclosed |
| EP-2591675-A1 | Heteroaryl amide derivatives | H. Lundbeck A/S (DK) | 2013-05-15 | — | — | EP | disclosed |
| EP-2591675-A1 | Heteroaryl amide derivatives | H. Lundbeck A/S (DK) | 2013-05-15 | — | — | EP | disclosed |
| US-8431593-B2 | Heteroaryl amide derivatives | H. LUNDBECK A/S (DK) | 2013-04-30 | — | — | US | disclosed |
| US-8431593-B2 | Heteroaryl amide derivatives | H. LUNDBECK A/S (DK) | 2013-04-30 | — | — | US | disclosed |
| US-8431593-B2 | Heteroaryl amide derivatives | H. LUNDBECK A/S (DK) | 2013-04-30 | — | — | US | disclosed |
| US-20100216763-A1 | Heteroaryl Amide Derivatives | H. LUNDBECK A/S (DK) | 2010-08-26 | — | — | US | disclosed |
| US-20100216763-A1 | Heteroaryl Amide Derivatives | H. LUNDBECK A/S (DK) | 2010-08-26 | — | — | US | disclosed |
| US-20100216763-A1 | Heteroaryl Amide Derivatives | H. LUNDBECK A/S (DK) | 2010-08-26 | — | — | US | disclosed |
| CN-101621931-A | Heteroaryl amide derivatives | LUNDBECK & CO AS H | 2010-01-06 | — | — | CN | disclosed |
| EP-2096923-A2 | HETEROARYL AMIDE DERIVATIVES | H. Lundbeck A/S (DK) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008066789-A2 | HETEROARYL AMIDE DERIVATIVES | H. LUNDBECK A/S (DK) | 2008-06-05 | — | — | WO | disclosed |
| WO-2008066789-A2 | HETEROARYL AMIDE DERIVATIVES | H. LUNDBECK A/S (DK) | 2008-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216763-A1 | Heteroaryl Amide Derivatives | HCAR2, PIGS, GPR52 | P2RX7 508/4885ADORA2A 186/4885CA2 3825/4885 |
| US-20130172549-A1 | Heteroaryl amide derivatives | HCAR2, PIGS, GPR52 | P2RX7 508/4885ADORA2A 186/4885CA2 3825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.