SCHEMBL30216641

SCHEMBL30216641

COc1cc2c(Oc3ccc(Br)cc3F)ccnc2cc1OCc1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MET P08581 15/20 0.58
KDR P35968 2/20 0.58
MST1R Q04912 2/20 0.58
EGFR P00533 1/20 0.54
HGF P14210 1/20 0.54
AXL P30530 2/20 0.51
FGFR2 P21802 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21408242 1.00 MET (0.58) METKDRMST1REGFRHGF
SCHEMBL13787641 0.89 MET (0.59) METKDRMST1RHGFAXL
SCHEMBL5223147 0.88 MET (0.58) METKDRMST1RHGFAXL
SCHEMBL3913728 0.88 EGFR (0.63) METKDRMST1REGFRAXL
SCHEMBL30216648 0.88 EGFR (0.63) METKDRMST1REGFRAXL
SCHEMBL31412927 0.88 AXL (0.61) METKDRMST1RHGFAXL
SCHEMBL372031 0.88 AXL (0.61) METKDRMST1RHGFAXL
Ammonia Solution, Strong SCHEMBL2063874 0.87 MET (0.57) METKDRMST1RHGFAXL
SCHEMBL16933077 0.87 AXL (0.60) METKDRMST1RHGFAXL
SCHEMBL4421590 0.87 TRPA1 (0.61) METKDREGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112313213-B 3-amino pyrazole compound and application thereof 上海海和药物研究开发股份有限公司 2023-01-31 CN disclosed