Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.52 |
| ▸ | LMNA | P02545 | 7/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL302172 | 0.82 | LMNA (0.49) | MAPTLMNAHTTGAASMN1; SMN2 | |
| SCHEMBL302170 | 0.80 | LMNA (0.53) | MAPTLMNAHTTGAASMN1; SMN2 | |
| SCHEMBL301695 | 0.79 | GAA (0.76) | MAPTLMNAHTTGAACACNA1H | |
| SCHEMBL3278531 | 0.76 | HTT (0.57) | MAPTLMNAHTTGAACACNA1H | |
| SCHEMBL3377228 | 0.76 | MAPT (0.74) | MAPTLMNAHTTGAASMN1; SMN2 | |
| SCHEMBL3235755 | 0.75 | HTT (0.57) | MAPTLMNAHTTGAACACNA1H | |
| SCHEMBL3279971 | 0.75 | MAPT (0.61) | MAPTLMNAHTTGAACACNA1H | |
| SCHEMBL1964073 | 0.74 | GAA (0.55) | MAPTLMNAHTTGAACACNA1H | |
| SCHEMBL14401108 | 0.74 | POLB (0.53) | MAPTSMN1; SMN2ALDH1A1KMT2AKDM4E | |
| SCHEMBL3377793 | 0.73 | MAPT (0.64) | MAPTLMNAHTTGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500835-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2334637-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-06-22 | — | — | EP | claimed |
| WO-2010023446-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |
| EP-2334637-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-06-22 | — | — | EP | disclosed |