Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL302172 | 0.89 | LMNA (0.49) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL1967123 | 0.84 | LMNA (0.68) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL302171 | 0.80 | MAPT (0.52) | LMNAALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL2212915 | 0.79 | MEN1 (0.58) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL2189346 | 0.77 | LMNA (0.85) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3377793 | 0.75 | MAPT (0.64) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL302889 | 0.73 | LMNA (0.54) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL325167 | 0.73 | MEN1 (0.52) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3378728 | 0.73 | MAPT (0.70) | LMNAALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL2211492 | 0.72 | MEN1 (0.53) | LMNAALDH1A1KMT2AMEN1FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500835-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2334637-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-06-22 | — | — | EP | claimed |
| WO-2010023446-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |