Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.32 |
| ▸ | VDR | P11473 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29237475 | 1.00 | DGAT2 (0.33) | DGAT2CDK8NR1H2NR1H3DNMT3B | |
| SCHEMBL30967771 | 1.00 | DGAT2 (0.33) | DGAT2CDK8NR1H2NR1H3DNMT3B | |
| SCHEMBL29237384 | 0.92 | DGAT2 (0.32) | DGAT2CDK8DNMT3BVDRPPARD | |
| SCHEMBL30217164 | 0.92 | DGAT2 (0.32) | DGAT2CDK8DNMT3BVDRPPARD | |
| SCHEMBL29237406 | 0.89 | DGAT2 (0.34) | DGAT2CDK8DNMT3BVDRPPARD | |
| SCHEMBL30217287 | 0.89 | DGAT2 (0.34) | DGAT2CDK8DNMT3BVDRPPARD | |
| SCHEMBL30967803 | 0.89 | DGAT2 (0.34) | DGAT2CDK8NR1H2NR1H3DNMT3B | |
| SCHEMBL30217176 | 0.89 | DGAT2 (0.34) | DGAT2CDK8NR1H2NR1H3DNMT3B | |
| SCHEMBL30216992 | 0.87 | MTNR1A (0.38) | DGAT2CDK8DNMT3BROCK2ROCK1 | |
| SCHEMBL29237332 | 0.87 | MTNR1A (0.38) | DGAT2CDK8DNMT3BROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4396179-A1 | INDOLE COMPOUNDS AND METHODS OF USE | GENZYME CORPORATION (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023034992-A1 | INDOLE COMPOUNDS AND METHODS OF USE | GENZYME CORPORATION (US) | 2023-03-09 | — | — | WO | disclosed |