Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29237231 | 1.00 | SIRT2 (0.42) | SIRT2BRD4CYP4F2CYP4A11EPHX2 | |
| SCHEMBL30216977 | 0.79 | SIRT2 (0.43) | SIRT2BRD4CYP4F2CYP4A11CYP11B1 | |
| SCHEMBL29237217 | 0.74 | BRD4 (0.42) | SIRT2BRD4CYP4F2CYP4A11EPHX2 | |
| SCHEMBL693047 | 0.74 | SIRT2 (0.50) | SIRT2BRD4CYP4F2CYP4A11CYP11B1 | |
| SCHEMBL22365351 | 0.74 | FFAR1 (0.56) | — | |
| SCHEMBL698078 | 0.73 | CYP4F2 (0.55) | SIRT2BRD4CYP4F2CYP4A11CYP11B1 | |
| SCHEMBL9545043 | 0.72 | KMT2A (0.54) | SIRT2 | |
| SCHEMBL7716761 | 0.72 | SIRT2 (0.51) | SIRT2BRD4CYP4F2CYP4A11CYP11B1 | |
| SCHEMBL30967950 | 0.72 | SIRT2 (0.44) | SIRT2BRD4CYP4F2CYP4A11CYP11B1 | |
| SCHEMBL30217084 | 0.72 | SIRT2 (0.44) | SIRT2BRD4CYP4F2CYP4A11CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4396179-A1 | INDOLE COMPOUNDS AND METHODS OF USE | GENZYME CORPORATION (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023034992-A1 | INDOLE COMPOUNDS AND METHODS OF USE | GENZYME CORPORATION (US) | 2023-03-09 | — | — | WO | disclosed |