Sugi Predict

Sugi Predict / Compounds / Bromide

Bromide

Bromide

SCHEMBL30217465

O=C(COc1c(Br)cccc1C[P+](c1ccccc1)(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1F.[Br-]

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 2/20 0.36
▸ NPC1 O15118 1/20 0.36
▸ HPGD P15428 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ PPARA Q07869 6/20 0.36
▸ PPARG P37231 5/20 0.36
▸ CCKAR P32238 2/20 0.34
▸ CCKBR P32239 2/20 0.34
▸ LMNA P02545 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ GRM4 Q14833 1/20 0.34
▸ MRGPRX4 Q96LA9 2/20 0.34
▸ AKR1B1 P15121 1/20 0.34
▸ CTSB P07858 2/20 0.34
▸ ALDH1A1 P00352 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ ACLY P53396 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL25405668 1.00 RAB9A (0.36) RAB9ANPC1HPGDSMN1; SMN2PPARA
SCHEMBL30217421 0.84 RAB9A (0.45) RAB9ANPC1HPGDSMN1; SMN2LMNA
SCHEMBL23980856 0.84 RAB9A (0.45) RAB9ANPC1HPGDSMN1; SMN2LMNA
SCHEMBL30217445 0.83 PTGDR2 (0.40) RAB9ANPC1HPGDSMN1; SMN2LMNA
SCHEMBL23980879 0.83 PTGDR2 (0.40) RAB9ANPC1HPGDSMN1; SMN2LMNA
SCHEMBL26304940 0.81 RAB9A (0.37) RAB9ANPC1HPGDSMN1; SMN2PPARA
SCHEMBL29149922 0.79 KMT2A (0.43) RAB9ANPC1HPGDSMN1; SMN2LMNA
SCHEMBL23980864 0.74 MAPT (0.44) RAB9ANPC1HPGDSMN1; SMN2LMNA
SCHEMBL30217405 0.74 MAPT (0.44) RAB9ANPC1HPGDSMN1; SMN2LMNA
SCHEMBL29924435 0.74 LMNA (0.44) RAB9ANPC1HPGDSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12552791-B2 Heterocyclic GLP-1 agonists GASHERBRUM BIO, INC. (US) 2026-02-17 — — US disclosed
EP-4143183-B1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO INC (US) 2025-10-22 — — EP disclosed
US-20250214999-A1 HETEROCYCLIC GLP-1 AGONISTS SHOUTI INC. 2025-07-03 — — US disclosed
EP-4143183-A1 HETEROCYCLIC GLP-1 AGONISTS Gasherbrum Bio, Inc. (US) 2023-03-08 — — EP disclosed
CN-115667250-A Heterocyclic GLP-1 agonists 加舒布鲁姆生物公司 2023-01-31 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12552791-B2 Heterocyclic GLP-1 agonists GLP1R, NPY1R, NPY2R RAB9A 1582/4885NPC1 795/4885HPGD 3363/4885
US-20250214999-A1 HETEROCYCLIC GLP-1 AGONISTS GLP1R, GIPR, GCGR RAB9A 788/4885NPC1 1207/4885HPGD 919/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.