Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | TPO | P07202 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LPO | P22079 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.32 |
| ▸ | KDM5A | P29375 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21681604 | 0.81 | KDM4E (0.49) | KDM4EHSD17B10ALDH1A1HPGDRAB9A | |
| SCHEMBL26662250 | 0.80 | KDM4E (0.48) | KDM4EHSD17B10ALDH1A1HPGDRAB9A | |
| SCHEMBL16691060 | 0.78 | MAPT (0.41) | KDM4EHSD17B10ALDH1A1HPGDRAB9A | |
| SCHEMBL26662277 | 0.77 | KDM4E (0.45) | KDM4EHSD17B10ALDH1A1HPGDRAB9A | |
| SCHEMBL20076031 | 0.73 | KDM4E (0.41) | KDM4EHSD17B10ALDH1A1HPGDRAB9A | |
| SCHEMBL20074182 | 0.71 | ALDH1A1 (0.47) | KDM4EHSD17B10ALDH1A1HPGDRAB9A | |
| SCHEMBL20160759 | 0.70 | KDM4E (0.47) | KDM4EHSD17B10ALDH1A1HPGDRAB9A | |
| SCHEMBL23062819 | 0.70 | SMN1; SMN2 (0.41) | KDM4EHSD17B10ALDH1A1HPGDRAB9A | |
| SCHEMBL20075837 | 0.69 | KDM4E (0.36) | KDM4EHSD17B10ALDH1A1HPGDRAB9A | |
| SCHEMBL23271256 | 0.69 | SMN1; SMN2 (0.41) | KDM4EHSD17B10ALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4153593-A1 | CGAS INHIBITING TRIAZOLOPYRIMIDONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-03-29 | — | — | EP | disclosed |
| CN-115667265-A | CGAS-inhibiting triazolopyrimidinone derivatives | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |