SCHEMBL30218709

SCHEMBL30218709

CC(C)(C)OC(=O)N1CCC2(CCCN2Cc2cc(-n3cccn3)cc(C(F)(F)F)c2)CC1

nearest known ligand 0.52

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 8/20 0.49
TACR1 P25103 1/20 0.45
GPR119 Q8TDV5 1/20 0.43
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20566495 1.00 MGLL (0.49) MGLLTACR1GPR119ALDH1A1
SCHEMBL25487662 0.89 MGLL (0.49) MGLLGPR119
SCHEMBL20570797 0.88 MGLL (0.53) MGLL
SCHEMBL20567352 0.86 MGLL (0.65) MGLL
SCHEMBL30302098 0.86 MGLL (0.65) MGLL
SCHEMBL20503512 0.85 MGLL (0.56) MGLLTACR1ALDH1A1
SCHEMBL24970488 0.82 MGLL (0.62) MGLL
SCHEMBL20166145 0.82 MGLL (0.54) MGLLTACR1ALDH1A1
SCHEMBL29446971 0.82 MGLL (0.54) MGLLTACR1ALDH1A1
SCHEMBL29417702 0.81 MGLL (0.53) MGLLTACR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116473965-B Pyrazole MAGL inhibitors H.隆德贝克有限公司 2025-03-18 CN disclosed
CN-116473965-A Pyrazole MAGL inhibitors H.隆德贝克有限公司 2023-07-25 CN disclosed
CN-110678456-B Pyrazole MAGL inhibitors H.隆德贝克有限公司 2023-05-02 CN disclosed
EP-3630744-B1 PYRAZOLE MAGL INHIBITORS H LUNDBECK AS (DK) 2023-01-25 EP disclosed