Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | BCR | P11274 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28986234 | 1.00 | RAPGEF4 (0.43) | RAPGEF4GRM4LRRK2MEN1KMT2A | |
| SCHEMBL6489892 | 0.73 | RAPGEF4 (0.49) | RAPGEF4GRM4MEN1KMT2AF2 | |
| SCHEMBL8973678 | 0.71 | RAPGEF4 (0.54) | RAPGEF4GRM4MEN1KMT2AF2 | |
| SCHEMBL11916208 | 0.69 | ULK1 (0.46) | LRRK2FGFR1KDRAXLPRKCI | |
| SCHEMBL30219582 | 0.69 | ULK1 (0.46) | LRRK2FGFR1KDRAXLPRKCI | |
| SCHEMBL7813159 | 0.68 | PIK3CG (0.57) | MEN1KMT2APDGFRBPLK1PIK3CG | |
| SCHEMBL16881716 | 0.68 | RAPGEF4 (0.50) | RAPGEF4GRM4MEN1KMT2AKDM4E | |
| SCHEMBL7396187 | 0.68 | GAA (0.59) | RAPGEF4GRM4MEN1KMT2A | |
| SCHEMBL15380926 | 0.67 | CDK2 (0.54) | LRRK2KITFGFR1KDRFLT3 | |
| SCHEMBL3381089 | 0.67 | CNR2 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109810110-B | Compound with 2-aminopyrimidine structure, preparation method and application thereof | 中国科学院上海药物研究所 | 2023-01-24 | — | — | CN | disclosed |