Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24046542 | 1.00 | CYP3A4 (0.41) | CYP3A4KDM1ASMN1; SMN2HTTMEN1 | |
| SCHEMBL30219745 | 0.76 | RXFP1 (0.41) | CYP3A4SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL25695757 | 0.75 | CYP1A2 (0.46) | CYP3A4MAPTDRD2DRD4 | |
| SCHEMBL25695740 | 0.75 | CYP3A4 (0.41) | CYP3A4KDM1ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL30219722 | 0.72 | ALDH1A1 (0.43) | CYP3A4SMN1; SMN2MAPTMAPK1GAA | |
| SCHEMBL24046641 | 0.72 | ALDH1A1 (0.43) | CYP3A4SMN1; SMN2MAPTMAPK1GAA | |
| SCHEMBL8342820 | 0.68 | SLC6A4 (0.50) | CYP3A4KDM1ASMN1; SMN2NPSR1MAPT | |
| SCHEMBL11463792 | 0.66 | KDM1A (0.48) | CYP3A4KDM1ASMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL13599422 | 0.65 | SLC6A2 (0.57) | CYP3A4KDM1AMEN1KMT2ANPSR1 | |
| SCHEMBL9917301 | 0.65 | CYP3A4 (0.48) | CYP3A4KDM1ANPSR1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4153175-A1 | PIPERIDINE-2,6-DIONES AS SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | Dana-Farber Cancer Institute, Inc. (US) | 2023-03-29 | — | — | EP | disclosed |