Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 6/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30219766 | 0.81 | CYP1A2 (0.46) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL24046370 | 0.81 | CYP1A2 (0.46) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL25695756 | 0.79 | MEN1 (0.51) | CYP1A2CYP2C19CYP3A4MAPT | |
| SCHEMBL6675557 | 0.78 | MAOA (0.63) | CYP1A2CYP2D6CYP2C19CYP3A4ROCK1 | |
| SCHEMBL18994858 | 0.76 | NOS1 (0.64) | CYP1A2CYP2D6CYP2C19CYP3A4NOS1 | |
| SCHEMBL21153746 | 0.76 | CYP1A2 (0.58) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL30219764 | 0.75 | CYP3A4 (0.41) | CYP3A4DRD2DRD4MAPT | |
| SCHEMBL24046542 | 0.75 | CYP3A4 (0.41) | CYP3A4DRD2DRD4MAPT | |
| SCHEMBL25695740 | 0.75 | CYP3A4 (0.41) | CYP3A4CYP19A1NOS1SIGMAR1NOS3 | |
| SCHEMBL25695746 | 0.75 | SIGMAR1 (0.51) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192644-A1 | PIPERIDINE-2,6-DIONES AS SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192644-A1 | PIPERIDINE-2,6-DIONES AS SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | IKZF2, IKZF1, NUTF2 | CYP1A2 158/4885CYP2D6 689/4885CYP2C19 2351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.