Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1980340 | 1.00 | KDM4E (0.40) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL24073391 | 0.79 | LMNA (0.39) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL30223290 | 0.79 | LMNA (0.39) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL15845739 | 0.78 | KDM4E (0.40) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL31355572 | 0.78 | KDM4E (0.37) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL4622913 | 0.78 | KDM4E (0.37) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL1285563 | 0.76 | PDK1 (0.38) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL15845612 | 0.73 | KDM4E (0.42) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL1983314 | 0.73 | KDM4E (0.57) | KDM4EPDK1PDK2PDK3PDK4 | |
| SCHEMBL2432483 | 0.71 | MEN1 (0.44) | PDK1PDK2PDK3PDK4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697993-B | Pyrimidine compounds as AXL inhibitors | 南京正大天晴制药有限公司 | 2024-12-10 | — | — | CN | disclosed |
| CN-115697993-A | Pyrimidines as AXL inhibitors | 南京正大天晴制药有限公司 | 2023-02-03 | — | — | CN | disclosed |