Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 5/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31355572 | 0.82 | KDM4E (0.37) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL4622913 | 0.82 | KDM4E (0.37) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL1284990 | 0.77 | KDM4E (0.53) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL30223299 | 0.76 | KDM4E (0.40) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL1980340 | 0.76 | KDM4E (0.40) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL31596297 | 0.76 | PDK1 (0.39) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL24073391 | 0.73 | LMNA (0.39) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL30223290 | 0.73 | LMNA (0.39) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL30937617 | 0.72 | ALDH1A1 (0.41) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL31567716 | 0.69 | PDK1 (0.57) | PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443108-A1 | 1-(2-ALKYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-PYRROLIDIN-3-YLAMINE ACYL COMPOUNDS | Ferrer Internacional, S.A. (ES) | 2012-04-25 | — | — | EP | disclosed |
| US-20120088809-A1 | 1-(2-ALKYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-PYRROLIDIN-3-YLAMINE ACYL COMPOUNDS | FERRER INTERNACIONAL, S.A. (ES) | 2012-04-12 | — | — | US | disclosed |
| US-20120088809-A1 | 1-(2-ALKYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-PYRROLIDIN-3-YLAMINE ACYL COMPOUNDS | FERRER INTERNACIONAL, S.A. (ES) | 2012-04-12 | — | — | US | disclosed |
| EP-2266975-A1 | 1-(2-alkyl-2,3-dihydro-benzofuran-4-yl)-pyrrolidin-3-ylamine acyl compounds | Ferrer Internacional, S.A. (ES) | 2010-12-29 | — | — | EP | disclosed |
| EP-2266975-A1 | 1-(2-alkyl-2,3-dihydro-benzofuran-4-yl)-pyrrolidin-3-ylamine acyl compounds | Ferrer Internacional, S.A. (ES) | 2010-12-29 | — | — | EP | disclosed |
| WO-2010145989-A1 | 1-(2-ALKYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-PYRROLIDIN-3-YLAMINE ACYL COMPOUNDS | FERRER INTERNACIONAL S.A. (ES) | 2010-12-23 | — | — | WO | disclosed |
| WO-2010145989-A1 | 1-(2-ALKYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-PYRROLIDIN-3-YLAMINE ACYL COMPOUNDS | FERRER INTERNACIONAL S.A. (ES) | 2010-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088809-A1 | 1-(2-ALKYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-PYRROLIDIN-3-YLAMINE ACYL COMPOUNDS | MTNR1A, MTNR1B, TPH2 | PDK1 2221/4885PDK2 836/4885PDK3 1557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.