Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.42 |
| ▸ | CDK9 | P50750 | 5/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.42 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30227987 | 0.92 | DPP4 (0.45) | KDM4EHPGDALDH1A1CCNT1CDK9 | |
| SCHEMBL30228249 | 0.84 | NPC1 (0.42) | KDM4EHPGDALDH1A1L3MBTL1GAA | |
| SCHEMBL30227932 | 0.82 | ALDH1A1 (0.43) | KDM4EHPGDALDH1A1CCNT1CDK9 | |
| SCHEMBL30228221 | 0.82 | NPC1 (0.40) | KDM4EHPGDALDH1A1GAANPC1 | |
| SCHEMBL30228041 | 0.80 | KDM4E (0.43) | KDM4EHPGDALDH1A1L3MBTL1MAPT | |
| SCHEMBL30227908 | 0.80 | ALDH1A1 (0.44) | KDM4EHPGDALDH1A1L3MBTL1NPC1 | |
| SCHEMBL30360867 | 0.76 | ALDH1A1 (0.55) | KDM4EHPGDALDH1A1PTGS2DPP4 | |
| SCHEMBL26504356 | 0.76 | ALDH1A1 (0.55) | KDM4EHPGDALDH1A1PTGS2DPP4 | |
| SCHEMBL30228316 | 0.75 | SLC18A1 (0.47) | KDM4EHPGDALDH1A1L3MBTL1MAPT | |
| SCHEMBL20839474 | 0.75 | ALDH1A1 (0.54) | KDM4EHPGDALDH1A1PTGS2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |