Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228284 | 0.83 | KCNA3 (0.52) | ALDH1A1RAB9ANPC1KCNA3HPGD | |
| SCHEMBL30227982 | 0.81 | KCNA3 (0.55) | ALDH1A1KCNA3HPGDSMN1; SMN2 | |
| SCHEMBL30228356 | 0.80 | PLA2G7 (0.46) | ALDH1A1KCNA3TP53HPGDCYP2C19 | |
| SCHEMBL30228398 | 0.80 | NPC1 (0.51) | MAPK14ALDH1A1RAB9ANPC1KCNA3 | |
| SCHEMBL30228193 | 0.79 | PLA2G7 (0.45) | ALDH1A1KCNA3HPGDCYP2C19 | |
| SCHEMBL30228438 | 0.79 | KCNA3 (0.59) | ALDH1A1RAB9ANPC1KCNA3TP53 | |
| SCHEMBL30228546 | 0.76 | KCNA3 (0.52) | ALDH1A1KCNA3TP53HPGD | |
| SCHEMBL30228032 | 0.76 | PLA2G7 (0.62) | MAPK14ALDH1A1RAB9ANPC1KCNA3 | |
| SCHEMBL20839382 | 0.76 | ALDH1A1 (0.54) | ALDH1A1RAB9AHPGDCYP2C19SMN1; SMN2 | |
| SCHEMBL30228103 | 0.74 | KCNA3 (0.48) | ALDH1A1KCNA3HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |