Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 4/20 | 0.56 |
| ▸ | IGLV6-57 | P01721 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CCR4 | P51679 | 1/20 | 0.43 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228307 | 0.86 | KCNA3 (0.51) | KCNA3IGLV6-57ALDH1A1L3MBTL1HPGD | |
| SCHEMBL30228053 | 0.85 | KCNA3 (0.50) | KCNA3IGLV6-57ALDH1A1L3MBTL1HPGD | |
| SCHEMBL31710568 | 0.84 | IGLV6-57 (0.52) | KCNA3IGLV6-57ALDH1A1L3MBTL1HPGD | |
| SCHEMBL30228123 | 0.83 | IGLV6-57 (0.51) | KCNA3IGLV6-57ALDH1A1L3MBTL1HPGD | |
| SCHEMBL30227938 | 0.83 | IGLV6-57 (0.51) | KCNA3IGLV6-57ALDH1A1L3MBTL1HPGD | |
| SCHEMBL14111529 | 0.83 | CA9 (0.62) | ALDH1A1HPGDMAPTCA12CA9 | |
| SCHEMBL30228263 | 0.82 | KCNA3 (0.47) | KCNA3IGLV6-57ALDH1A1L3MBTL1HPGD | |
| SCHEMBL29401382 | 0.81 | IGLV6-57 (0.72) | IGLV6-57ALDH1A1L3MBTL1HPGDHSD17B10 | |
| SCHEMBL30228412 | 0.81 | KCNA3 (0.62) | KCNA3ALDH1A1L3MBTL1HPGDHSD17B10 | |
| SCHEMBL67970 | 0.81 | IGLV6-57 (0.72) | IGLV6-57ALDH1A1L3MBTL1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250326732-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-10-23 | — | — | US | disclosed |
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250326732-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | POLRMT, TFAM, POLM | KCNA3 4258/4885IGLV6-57 4814/4885ALDH1A1 3178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.