Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.73 |
| ▸ | HPGD | P15428 | 8/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | AR | P10275 | 1/20 | 0.58 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | IGLV6-57 | P01721 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228258 | 0.89 | ALDH2 (0.73) | ALDH1A1HPGDKDM4ERECQLAR | |
| SCHEMBL30228298 | 0.88 | ALDH1A1 (0.77) | ALDH1A1HPGDKDM4ERECQLAR | |
| SCHEMBL20839059 | 0.88 | ALDH1A1 (0.77) | ALDH1A1HPGDKDM4ERECQLAR | |
| SCHEMBL20839056 | 0.88 | ALDH1A1 (0.77) | ALDH1A1HPGDKDM4ERECQLAR | |
| SCHEMBL26104548 | 0.87 | ALDH1A1 (0.71) | ALDH1A1HPGDKDM4ERECQLAR | |
| SCHEMBL21629541 | 0.84 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ERECQLAR | |
| SCHEMBL21629540 | 0.84 | ALDH1A1 (1.00) | ALDH1A1HPGDKDM4ERECQLAR | |
| SCHEMBL22431698 | 0.83 | ALDH1A1 (0.68) | ALDH1A1HPGDKDM4ERECQLAR | |
| SCHEMBL22431741 | 0.82 | ALDH1A1 (0.67) | ALDH1A1HPGDKDM4ERECQLAR | |
| SCHEMBL30228044 | 0.81 | ALDH1A1 (0.60) | ALDH1A1HPGDKDM4ERECQLAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |