Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH2 | P05091 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.64 |
| ▸ | HPGD | P15428 | 10/20 | 0.64 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KLK7 | P49862 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228157 | 0.89 | ALDH2 (0.73) | ALDH2ALDH1A1HPGDARKDM4E | |
| SCHEMBL30228225 | 0.89 | ALDH1A1 (0.73) | ALDH2ALDH1A1HPGDARKDM4E | |
| SCHEMBL21629539 | 0.84 | ALDH1A1 (0.80) | ALDH2ALDH1A1HPGDARKDM4E | |
| SCHEMBL21677082 | 0.82 | ALDH1A1 (0.72) | ALDH2ALDH1A1HPGDARKDM4E | |
| SCHEMBL30762949 | 0.80 | ALDH1A1 (0.65) | ALDH2ALDH1A1HPGDARKDM4E | |
| SCHEMBL20839119 | 0.80 | ALDH1A1 (0.65) | ALDH2ALDH1A1HPGDARKDM4E | |
| SCHEMBL20839174 | 0.79 | ALDH1A1 (0.59) | ALDH2ALDH1A1HPGDARKDM4E | |
| SCHEMBL20839176 | 0.79 | ALDH1A1 (0.59) | ALDH2ALDH1A1HPGDARKDM4E | |
| SCHEMBL20839098 | 0.79 | ALDH1A1 (0.64) | ALDH2ALDH1A1HPGDARKDM4E | |
| SCHEMBL30228044 | 0.79 | ALDH1A1 (0.60) | ALDH2ALDH1A1HPGDARKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250326732-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-10-23 | — | — | US | disclosed |
| US-20240368106-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2024-11-07 | — | — | US | disclosed |
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250326732-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | POLRMT, TFAM, POLM | ALDH2 461/4885ALDH1A1 3178/4885HPGD 2486/4885 |
| US-20240368106-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | POLRMT, ACAT1, TFAM | ALDH2 62/4885ALDH1A1 909/4885HPGD 882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.